迭代二步法估算阿米卡星的群体药动学参数

Estimating population pharmacokinetic parameters of amikacin by iterative two stage method

目的 :用迭代二步法估算阿米卡星的群体药动学参数。方法 :收集 5 8例呼吸系统感染病人静脉滴注阿米卡星的临床血药浓度监测数据 ,用荧光偏振免疫法测定阿米卡星血药浓度 ,用迭代二步法估算阿米卡星的群体及个体药动学参数。比较性别、年龄、体重、肌酐清除率等因素对药动学参数的影响。结果 :性别对药动学参数无影响 ,CL与CLcr呈正相关 ,Vd 与体重呈正相关。结论 :迭代二步法能较好地估算出阿米卡星的群体及个体药动学参数 。

OBJECTIVE To estimate population pharmacokinetic parameters of amikacin by iterative two stage method. METHODS Clinical data were collected from 58 patients with respiratory tract infection receiving amikacin by intravenous infusion. Concentrations of amikacin in serum were determined by fluorescence polarization immunoassay. Population pharmacokinetic parameters were estimated by iterative two stage method. The influence of sex, age, body weight and creatinine clearance on pharmacokinetic parameters was investigated. RESULTS It was shown that the pharmacokinetic parameters of amikacin were influenced by creatinine clearance and body weight. CONCLUSIONS Iterative two stage method is suitable for estimation of population pharmacokinetic parameters,optimizing individualizing dosage regimens and forecasting plasma concentration.