秦皮药材的质量评价

QUALITY EVALUATION OF CORTEX FRAXINI (QINPI)

目的 评价秦皮药材的质量 ,为药典标准修订及新药研究提供依据。方法 采用紫外分光度法定量分析秦皮有效部位的总香豆素 ;高效液相色谱法定量分析香豆素中的主要成份秦皮甲素、秦皮乙素、秦皮苷及秦皮亭。结果 秦皮中的总香豆素及其主要成份在枝皮中远较干皮高 ,并以枝条越细含量越高 ,干皮中含量较低 ,远不能达药典限度要求 ;秦皮饮片炮制过程中 ,“洗净 ,润透”过程对香豆素类成分影响较大。结论 建议药典将秦皮干皮与枝皮的含量限度分列 ,或者考虑干皮不作为其入药部位 ;炮制时不再洗与浸 ,直接干切。

OBJECTIVE To evaluate the quality of Cortex Fraxini (Qinpi),to provide basis for revising pharmacopoeia and to study new drugs.METHODS Using UV method to determine the content of total coumarins in Qinpi;and using HPLC method to determine the content of main component(aesculin,aesculetin,fraxin and fraxetin)in coumarins.RESULTS Total coumarins and main components in twig epidermis are more than in trunk epidermis,and the twig epidermis is thinner,the content is more.The content is few in trunk epidermis,and it can not reach limits provided from China pharmacopoeia;In the process of cutting up,'washing clean'and'moistening'influenced for the contents of coumarins.CONCLUSION The suggestion to leave lining limits of content in twig epidermis and dry epidermis each other,or consider that dry epidermis is not used as effective part;in the process of cutting up,no longer wash and soak,direct slice.