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翻译过程中mRNA的拓扑形态及其链构象分析

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摘要 对mRNA发夹结构和单链结构的理论模型构建,以及基于对X射线晶体衍射和NMR实验数据的模拟研究显示,在翻译过程中,核糖体上mRNA解折叠后的单链拓扑形态,与mRNA本身的发夹结构密切相关,均呈现为不同程度的螺旋与卷曲相间的构象.通过包括翻译速度在内的调节作用,这种构象可能会影响到新生肽链的折叠.
出处 《科学通报》 EI CAS CSCD 北大核心 2002年第1期25-30,共6页 Chinese Science Bulletin
基金 国家自然科学基金资助项目(批准号:39770418) 中国科学院知识创新工程重大前沿项目(编号:KJCX 1-08).
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