美托洛尔、卡托普利治疗慢性充血性心力衰竭的临床观察

Clinical Study of Captopril and Metoprolol in Treatment of Chronic Congestive Heart Failure

目的:探讨β受体阻滞剂和ACEI在心力衰竭中的应用。方法:124例CHF患者随机分为4组,分别单用和联用美托洛尔、卡托普利,并与常规用药组对照,疗程8个月,观察临床心功能、LVEF和再住院及病死率。结果:各治疗组再住院及病死率均低于对照组,尤以联用组显著。联用组显效率、有效率明显高于对照组,且显效率比单用组为高。治疗组LVEF疗后与疗前比较有较显著增高,且增幅与对照组增幅组间比较有显著性差异。结论:卡托普利和美托洛尔联用治疗慢性CHF有较好效果,可明显改善心功能,降低心衰再住院及病死率。

To explore the use of (3-receptor blockers and ACEI in the treatment of chronic congestive heart failure. Methods: 124 patients with chronic congestive heart failure were randomly devided into four groups.33 patients were randomized to conventional treatment group(control group) ,30 patients to captopril group,30 patients to metoprolol group and 31 patients to meto-prolol plus captopril group (combination therapy group) . Results: The mortality and rehospitalization rate in treatment groups were lower than that in control group. There was more significant improvement in NYHA functional class in combination therapy group compared with control group, captopril group and metoprolo] group. After treatment LVEF in treatment groups was significantly increased, and the increment level was significantly more than that in control group. Conclusion: use of B-receptor blockers and ACEI based on conventional therapy may significantly improve the heart function of the patients with chronic congestive heart failure and reduce mortality and rehospitalization rate.