冠心病患者血浆内皮素和前列环素水平变化及临床意义

CHANGES OF PLASMA ET AND PGI_2 CONCENTRATIONS IN PATIENTS WITH CORONARY HEART DISEASE AND THEIR CLINICAL SIGNIFICANCE

目的 :观察血浆内皮素 ( ET)及前列环素 ( PGI2 )的代谢产物 6 -keto-PGF1α在稳定性心绞痛 ( SAP)、不稳定型心绞痛 ( UAP)、急性心肌梗死 ( AMI)病人血浆中浓度变化 ,探讨其在 UAP、AMI发病中的意义。方法 :检测了 2 8例 SAP、4 8例 UAP、2 3例 AMI及 2 6例健康人血浆 ET、6 -keto-PGF1α浓度 ,分析各组间差异。结果 :冠心病病人血浆 ET增高的同时 ,血 6 -keto-PGF1α下降 ,尤以 AMI第 1天和 UAP患者为明显。结论 :冠心病病人存在血管内皮细胞受损 ,其分泌的 ET与 PGI2 失衡 ,诱发冠状动脉痉挛 ,促发了 UAP和 AMI的发生。

Objective:To observe the changes of ET,PGI 2 and 6 keto PGF 1α concentration in plasma of patients with SAP,UAP,and AMI and explore their significance in the pathogenesis of UAP and AMI.Methods:Plasma concentrations of ET and 6 keto PGF 1α were measured in 23 AMI patients,48 UAP patients,28 SAP patients and 26 control cases respectively.Difference of the above parameters between two groups was analyzed.Results:The plasma ET concentration in patients with coronary heart disease increased,the plasma 6 keto PGF 1α concentration decreased,especially in patients with UAP and AMI.Conclusion:Increase of ET and reduction of PGI 2 could induce coronary vasospasm;change of plasma ET and PGI 2 concentration played an important pathogenetic role in UAP and AMI.