不同剂量降纤酶治疗脑梗塞患者高粘滞血症的临床研究

Clinical Study on Curative Effect of Defibrise in Different Doses against Blood Hypervicosity Syndrome of Cerebral Infarction Patients

目的:观察不同剂量降纤酶治疗脑梗塞患者高脂血症、高粘滞血症(BHS)的临床疗效。方法:对95例脑梗塞患者应用不同剂量降纤酶20U或10U加入生理盐水250mL中静滴1h,每日1次,使用3d,并与丹参注射液,每日20mL,连用10d作比较。结果:降纤酶具有明显降血脂,降低纤维蛋白原和改善血液流变性作用。结论:大剂量降纤酶治疗脑梗塞患者BHS疗效优于中等剂量和对照组,且降纤酶降血脂作用明显,安全性好。

To observe the curative effect of defibrise in different doses against hyperlipemia and blood hyperviscosity syndrome of cerebral infarction patients.Methods:95 cases of cerebral infarction patients were devided into 3 groups. Group A(35 cases) was administered by intravenous drip of defibrise 20U of combined with 250mL of normal saline for Ih, once per day for 3 days. Group B( 30 case) was administered by same drugs( 10U of defibrise) . In control group (groupC, 30 cases) 20mL of salvia mil-tiorrhiza injection was added to 250mL of 5% glucose for intravenous drip for 10 days. Results: Defibrise has remarkable effect of decreasing levels of blood lipid and fibrinogen and improving hemorrheology. Conclusion: Defibrise is definitely effective in decreasing blood lipid and large dose of defibrise is superior to middle dose and control in curative effect against BHS of cerebral infarction patients .