中晚期原发性肝癌介入治疗后二期切除

Secondary resection after transcatheter hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma

目的 探讨中、晚期原发性肝癌介入治疗的方法及其对二期手术切除的价值。方法 对 14 0例不能手术切除的中、晚期原发性肝癌 ,经不同介入方法治疗。结果 2 0例获得二期切除 (二期切除率为 14 .3 % )。综合治疗组 (B组 )二期切除率和 5年生存率分别为 2 4.1% (14 / 5 8)和 47.1% ,高于单方法组 (A组 )的 7.3 % (6/ 82 )和 0 ,两组比较差异有显著性 (P均 <0 .0 1)。二期切除与非二期切除患者的 1,3 ,5年生存率分别为 95 .0 % ,63 .5 % ,3 2 .9%及 5 8.3 % ,17.6% ,5 .5 %。结论 介入方法治疗中、晚期原发性肝癌可获得二期手术切除。

Objective To evaluate the method of interventional treatment and value of secondary resection for unsectable hepatocellular carcinoma(HCC). Methods 140 patients with unsectable HCC were treated by different ways of interventional treatment. Results 20 patients were secondly resected (14.3%), The combination treatment(B group) had a secondary resection rate and a 5 years survival rate of 24.1% ,47.1% respectively. Combination treatment had better results than single treatment(A group ). One,3 and 5 years survival rate was 95.0% ,63.5% and 32.9% in secondary resection group and was 58.3% ,17.6% and 5.5% in unresectable group. Conclusion Interventional treatment method may get some unresectable HCC into second stage resection . Combination treatment was superior to single treatment in terms of secondary resection rate and 5 years survival rate.