新生儿重度窒息多脏器功能不全的研究

A study on multiple organ dysfunction syndrome in the neonates with perinatal severe asphyxia

目的 了解新生儿重度窒息后多脏器功能损害的程度、发生率及转归 ,探讨新生儿多脏器损害的影响因素及分度。 方法 对 112例重度窒息新生儿进行了回顾性研究。研究的器官定为脑、心、肾、肺、肝、胃肠道、代谢、血液 ,并将各器官损害的程度分为轻中度和重度。 结果 112例中除 6例死亡、2例放弃未查外 ,其余 10 4例中 ,发生MODS的为 5 3例 (占 5 1% )。窒息持续时间与MODS发生率受窒息程度的影响 ;窒息程度与MODS发生率又受窒息持续时间的影响。 结论 窒息程度、持续时间、神经系统症状等 。

Objective To investigate the severity,frequency and result of multiple organ dysfunction syndrome in neonates after perinatal severe asphyxia.Methods One hundred and twelve newborn infants with perinatal severe asphyxia were studied retrospectively.Brain,cardiac,renal,pulmonary,gastrointestinal,liver,metabolism and blood evaluations were selected for evaluation.Involved organs were classified as moderate or severe.Results Except six death and two abandoned,in one hundred and four infants,fifty three cases(51%)were diagnosed as MODS.duration of asphyxia and frequency of MODS were affected by the severity of asphyxia,The severity of asphyxia and frequenncy of MODS were affected by duration of asphyxia.The more severe was the asphyxia the more longer was the time of asphyxia and the more higher was the frequency of MODS,and the mortality was high.Conclusion The severity of asphyxia,the duration of asphyxia and the symptoms of nervous system are considered as early alert indications of MODS.