峰流量在吸烟者、COPD和肺心病患者中的改变及其临床意义

Change and Clinical Significance of PEF in Smokers, COPD and Cor Pulmonale Patients

目的 探讨峰流量 (peak expiratory flow,PEF,最大呼气流量 )在吸烟者、慢性阻塞性肺疾病(COPD)和肺心病患者中的改变及临床意义。方法 测定不同程度吸烟者 116例 ,缓解期 COPD患者 90例〔慢性支气管炎 (慢支 ) 4 3例 ,肺气肿 47例〕及缓解期肺心病患者 31例的 F- V曲线。选用的指标为 FVC、PEF、·V75、·V50 、·V2 5。结果 吸烟者和慢支患者 PEF实 /预 (% ) >84% ,属于正常范围 ;肺气肿和肺心病患者 PEF实 /预 (% )分别为44 %和 32 % ,随病情加重而依次下降。·V75%PEF% (% )在吸烟者和慢支患者为 87.7%～ 89.7% ,居正常范围 ;而在肺气肿和肺心病患者分别为 70 .7%和 41.9% ,随病情加重而依次下降。结论 PEF%和·V75%PEF% (% )

Objective To understand the change and clinical significance of PEF in smokers, COPD and cor pulmonale patients. Methods The F V curves were measured in 116 smokers, 90 COPD (43 with chronic bronchitis, 47 with emphysema )and 31 cor pulmonale patients in the ameliorated period. The indices selected were FVC, PEF, ·V 75 ,·V 50 and ·V 25 .Results The PEF% (measured values/predicted values) in smokers and chronic bronchitis patients were higher than 84%(i.e.percentages being within the normal range); they were 44% and 32% in patients with emphysema and cor pulmonale respectively and decreased with the severity of disease. The ·V 75 %PEF%(%) in smokers and chronic bronchitis patiens were 87.7%~89.7% (again, percentages being within the normal range); they were 70.7% and 41.9% in pateints with emphysema and cor pulmonale respectively and decreased with the severity of disease. The phenomenon that decrease was more conspicuous in ·V 75 % than in PEF% could be explained with the wave speed theory. Conclusion There is clinical significance in the degree of decrease in PEF% and ·V 75 %PEF%(%).