系统性红斑狼疮疾病活动指数与治疗的关系探讨

The Significance of Systemic Lupus Erythematosus Disease Activity Index in the Treatment of SLE.

目的探讨系统性红斑狼疮疾病活动指数(SLEDAI)对临床治疗的指导作用。方法以SLEDAI对每一例SLE患者入院前10天内和出院时的活动性进行评价;根据患者病情分别给予泼尼松、甲泼尼龙冲击、环磷酰胺冲击治疗。以SPSS统计软件进行相应统计学分析。结果①入院前和出院时SLEDAI均值比较t=8.65,P<0.001;②不同治疗分数患者SLEDAI比较差异有显著性;③泼尼松用量、甲泼尼龙或CTX冲击治疗均与SLEDAI正相关;④不同的治疗方法与不同的器官/系统活动性有关。结论SLEDAI是一较好的评价SLE活动性的指标,对临床治疗有较好的指导作用。对不同的器官/系统受累,宜选择不同的治疗方案。

Objective To study the clinical significance of systemic lupus erythematosus disease activity index(SLEDAI) in the treatement of SLE. Methods Disease activity of every patient with SLE 10 days before admission and before discharging was assessed using the SLEDAI system. The patients were treated separately with prednisone, pulse methylprednisolone and/or pulse cyclophosphamide according to their conditions. Statistical analysis was carried out using SPSS software. Results ①The difference of SLEDAI between the patients before admission and discharging was significant (P< 0.001). ②The difference of SLEDAI among different treatment groups was significant. ③There was a positive correlation between the dosage of prednisone, methylprednisone, cyclophosphamide and SLEDAI. ④Different treatment choice was associated with different organ/system involvement. Conclusion SLEDAI is an effective indicator in evaluating disease activity of SLE patients, which is useful in SLE treatment.