炼焦大气污染物和纯态多环芳烃诱发小鼠肺癌的病理学研究

Pathological examination of mice lung cancer induced by air pollutants in ,coking industry

用263只成年瑞士种小鼠,选用炼焦工业现场中大气污染物(焦油、焦炭粉尘)和纯态多环芳烃[二苯并(a,h)蒽、苯并(a)茈],经肺内注入法染毒,成功诱发出小鼠肺癌。其中肺腺癌占87.7％(50/57)其次为癌肉瘤,鳞状细胞癌,大细胞癌,淋巴瘤,间皮瘤等。电镜下观察了部分腺癌。发现,有的腺癌具有肺泡Ⅱ型上皮细胞的特点,有的腺癌具有Clara细胞的特点,多数腺癌具有上述两种腺癌细胞的共同特点。

263 swiss strain mice were used to research the carcinogenic capability of PAH and air pollutants(coal tar and coking dust) in coking industry. The histopathologieal change and formation of lung cancer in mice were observed under a microscope. The result shows that 57 pulmonary malignant tumors were found, of which the lung adenocareinomas reached 87.7%(50/57), and a small number of lung earcinosarcoma, squamocarcinoma, and large cell carcinoma were observed. Ultrastructural study indicates that some adenoearcinomas possessed the features of the alveolar Type Ⅱ cells alone, but others showed clara cell features alone, and third adenocarcinomas had the common features of both mentioned above.