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钠/碘同向转运体与放射性碘治疗 被引量：2

The sodium/iodide symporter and radioiodide therapy
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摘要 钠 /碘同向转运体 (NIS)是一种调节甲状腺及其他组织碘转运活性的膜蛋白。NIS在甲状腺的病理生理中发挥着关键性作用 ,它实现了甲状腺组织摄取碘并进行甲状腺激素的生物合成 ,实现了甲状腺功能亢进和分化型甲状腺癌的显像诊断和放射性碘治疗。近年来 ,对 NIS的进一步分子学研究表明 。 The sodium/iodide symporter (NIS) is an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and other tissues. NIS plays key roles in thyroid pathophysiology as the route by which iodide reaches the gland for thyroid hormone biosynthesis and as a means for diagnostic scintigraphic imaging and for radioiodide therapy in hyperthyroidism and thyoid cancer. The continued molecular analysis of NIS clearly holds the potential of an even greater impact on the diagnosis and radioiodide treatment of cancer, both in thyroid and beyond.
作者 陈立波
机构地区 上海市第六人民医院核医学科
出处 《国外医学（放射医学核医学分册）》 2001年第6期258-261,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 钠/碘同向转运体 放射性碘治疗 甲状腺癌 乳腺癌 前列腺癌 sodium/iodide sympertor radioiodide therapy thyroid cancer breast cancer prostate cancer
分类号 R817.5 [医药卫生—影像医学与核医学]
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参考文献30

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同被引文献27

  • 1胡莹莹,蒋宁一.^(131)Ⅰ治疗分化型甲状腺癌的现状和进展[J].国际放射医学核医学杂志,2006,30(6):343-346. 被引量：11
  • 2张晓明,冯珏,张文军,董慧兰,赵丽红,郭玉环,赵世静,何荣喜.核素唾液腺动态显像定量分析评价干燥综合征唾液腺功能的研究[J].中国医学影像技术,2007,23(4):608-612. 被引量：18
  • 3Carvalho DP,Ferreira AC.The inportance of sodium/iodide symporter (NIS) for thyroid cancer management.Arq Bras Endocrinol Metabol,2007,51(5):672-682.
  • 4Richard JR,Martin JS.The evolving role of I-131 for the treatment of differentiated thyroid carcinoma.J Nucl Med,2005,46(1):28-37.
  • 5Lionel S.Z,Orshi D,Yi L,et al.Kinetics of perrhenate uptake and comparative biodistribution of perrhenate,pertechnetate,and iodide by NaI Symporter-Expressing tissues in vivo.J Nucl Med,2004,45(3):500-507.
  • 6Newkirk KA,Ringel MD,Wartosky L,et al.The role of radioactive iodine in salivary gland dysfunction.Ear Nose Throat J,2000,79(6):460-468.
  • 7Arjan V,Fred RB,Fred KL,et al.Prebention and treatment of salivary gland hypofunction related to head and neck radiation therapy and chemotherapy.Supportive Cancer Therapy,2004,1(2):111-118.
  • 8Vinagre F,Santos A,Santos M,et al.Salivary gland scintigraphy in the evaluation of patients with sicca complains.Acta Reumato Port,2008,33(4):422-428.
  • 9Mandel L,Liu F.Salivary gland injury resulting from exposure to radioactive iodine:case reports.J Am Dent Assoc,2007,138(12):1582-1587.
  • 10Hasan R,Aakif U.K,Abid H,et al.Quantitative evaluation of salivary gland dysfunction after radioiodine therapy using salibary gland scintigraphy.Nucl Med Commun,2006,27(6):495-499.

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国外医学（放射医学核医学分册）
2001年 第6期

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