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FHIT基因研究进展 被引量：9

Advances of FHIT gene
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摘要 FHIT基因是定位于染色体 3p14.2区域的候选肿瘤抑制基因 ,在许多肿瘤 ,特别是环境致癌物引起的上皮肿瘤中经常发生改变 ,在辐射引起的癌症中也有改变 ,参与细胞周期和细胞凋亡的调控 ,但其作用的机理尚未完全阐明。 The FHIT gene located at chromosome 3p14.2 is a putative tumor suppressor gene. It is frequently altered in many tumors, particularly in tumors resulting from exposing to environmental carcinogens.In tumor that is caused by radiation, the FHIT gene is also altered. It is involved in the regulation of apoptosis and in cell cycle control. However, its mechanism is not completely clarified.
作者 林亚华 叶巧滔
机构地区 第二军医大学海医系放射医学教研室 中国人民解放军第
出处 《国外医学（放射医学核医学分册）》 2001年第6期275-279,共5页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 FHIT基因 肿瘤抑制基因 细胞凋亡 恶性肿瘤 辐射 FHIT gene tumor suppressor gene apoptosis neoplasm radiation
分类号 Q334.13 [生物学—遗传学]
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参考文献20

  • 1Ohta M,Inoue H,Cotticelli WG,et al.The FHIT gene,spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t (3; 8) breakpoint,is abnormal in digestive tract cancers[J].Cell,1996,84(4): 587-597.
  • 2Sard L,Accornero P,Tornielli S,et al.The tumorsuppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control [J].Proc Natl Acad Sci USA,1999,96 (15):8489-8492.
  • 3Ji L,Fang B,Yen N,et al.Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression[J].Cancer Res,1999,59(14) :3333-3339.
  • 4Barnes LD,Garrison PN,Siprashvili Z,et al.Fhit,a putative tumor suppressor in humans,is a dinucleoside 5',5'-P1,P3-triphosphate hydrolase [J].Biochemistry,1996,35(36):11529-11535.
  • 5Siprashvili Z,Sozzi G,Barnes LD,et al.Replacement of Fhit in cancer cells suppresses tumorigenicity [J].Proc Natl Acad Sci USA,1997,94(25):13771-13776.
  • 6Pace HC,Garrison PN,Robinson AK,et al.Genetic,biochemical,and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit [J].Proc Natl Acad Sci USA,1998,95(10):5484-5489.
  • 7Morikawa H,Nakagawa Y,Hashimoto K,et al.Frequent altered expression of fragile histidine triad protein in human colorectal adenomas[J].Biochcm Biophys Res Comrmn,2000,278 (1): 205-210.
  • 8Otterson GA,Xiao GH,Geradts J,et al.Protein expression and functional analysis of the FHIT gene in human tumor cells [J].J Natl Cancer Inst,1998,90(6): 426-432.
  • 9Pekarsky Y,Campiglio M,Siprashvili Z,et al.Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans [J].Proc Natl Acad Sci USA,1998,95(15):8744-8749.
  • 10Garinis GA,Gorgoulis VG,Mariatos G,et al.Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromesomal instability in non-small cell lung carcinomas (NSCLCs) [J].JPathol,2001,193(1): 55-65.

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国外医学（放射医学核医学分册）
2001年 第6期

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