强直性脊柱炎和类风湿关节炎患者内皮素-1、降钙素基因相关肽水平的临床观察

Studies on the role of ET-1 and CGRP in the pathophysiology of ankylosing spondylitis and rheumatoid arthritis

目的 :探讨内皮素 - 1(ET - 1)、降钙素基因相关肽 (CGRP)在强直性脊柱炎 (AS)和类风湿关节炎(RA)病理生理过程中的作用。方法 :用放射免疫法检测AS和RA患者血浆及关节液中ET - 1、CGRP含量 ,并与健康志愿 (HC)组进行比较。结果 :AS、RA组血浆ET - 1水平均明显高于HC组 (P <0 .0 1) ;AS组和RA组血浆CGRP水平均与HC组无显著差异 (P >0 .0 5 ) ;关节滑液中CGRP水平明显高于血浆 (P <0 .0 1) ,ET - 1水平明显低于血浆 (P <0 .0 1)。结论 :ET - 1、CGRP参与了AS、RA病理生理过程 ,但在AS、RA疾病过程中作用机制不同。

AIM: To clarify the role of endothelin-1(ET-1) and calcitonin gene related peptide(CGRP) in the pathophysiology of ankylosing spondylitis and rheumatoid arthritis.METHOD: Plasma/synovial fluid ET-1 and CGRP were measured by radio-immunoassay in patients with ankylosing spondylitis(AS) or rheumatoid arthritis(RA) and healthy control.RESULTS: ET-1 level in plasma of patients with AS and RA were significantly higher than that of healthy controls ( P <0.01). No difference was found in plasma CGRP level between AS or RA and healthy control ( P >0.05). CGRP level in synovial fluid was significantly higher than that in plasma ( P <0.01), but ET-1 level was significantly lower than in plasma ( P <0.01).CONCLUSION: These results suggest that ET-1 and CGRP play a pathogenic role in AS and RA.