干扰素对扩张型心肌病心功能的影响

Effect of Interferon on Cardiac Function in Dilated Cardiomyopathy

目的 观察干扰素治疗对扩张型心肌病心功能的影响。方法 选择从 1997年 10月～ 2 0 0 0年 4月间在我院住院和门诊病人 5 2例 ,随机分为干扰素治疗组和常规治疗组。在治疗前、治疗 1、3和 6个月后分别记录临床心功能分级 ,记录 2 4h室性早搏次数 ,心衰住院次数和上呼吸道感染次数 ;超声心动图定量分析心功能变化。对两组病人进行随访。干扰素治疗组除常规药物治疗外 ,加用干扰素 α(interferon α) 3 0 0万U隔天肌注 ,共3～ 6月。结果 临床及超声心动图结果发现干扰素组的心功能改善优于常规组 ;在治疗 6个月后两组差异有显著性 (P <0 .0 5 ) ;干扰素治疗组在减少室性早搏次数、上呼吸道感染次数和心衰次数方面优于常规治疗组。结论 干扰素对扩张型心肌病心功能的改善有较好作用。

Purpose To observe the effect of interferon-αon cardiac function in dilated cardiomyopathy(DCM). Methods Fifty-two cases with DCM were selected from Oct, 1997 to Apr, 2000. Twenty-five were male, 27 were female. The 52 cases were randomly divided into 2 groups, interferon group(31) and control group(21). Cardiac function, ventricular premature beats, times of hospitalization for heart failure and times of upper respiratory inflammation were recorded before therapy, 1 month, 3 months and 6 months after therapy. Interferon 300 million U intramuscular injection on every other day was given to interferon group, the treatment lasted for 3-6 months. Results Interferon group showed more effective amelioration than conventional group in cardiac function, ventricular premature beat, hospitalizations of heart failure and decreasing upper respiratory inflammation in DCM. Conclusions Interferon is an effective drug for DCM.