肥胖患者血清C-反应蛋白水平变化与代谢综合征的关系

Relationship of C-Reactive Protein to Metabolic Syndrome in Obese Subject

目的 比较肥胖患者急性期标志 -血清C 反应蛋白 (CRP)水平的变化并探讨与代谢综合征的关系。方法 选择 15 3例肥胖患者和 4 7例正常体重者 ,测定血清CRP水平 ,同时检测体重指数 (BMI)、腰围 (W )、腰臀比 (WHR)、血压、糖脂代谢参数、空腹胰岛素 (FIN)、胰岛素原 (PI)、胰岛素原 /胰岛素比值 (P/I) ,并对导致血清CRP改变的因素进行相关分析研究。结果 ( 1)肥胖组血清CRP高于体重正常组 (P <0 .0 0 1) ,单纯肥胖组与肥胖伴糖代谢异常组之间无明显差异 (P =0 .4 13 ) ;( 2 )肥胖组相关分析显示血清CRP与W、WHR、SBP、TG、PI、HOMA IR、P/I呈正相关 ;( 3 )矫正年龄和BMI后 ,血清CRP与SBP、WHR和RI仍存在相关性 ,与其他变量的相关性消失。结论 1、肥胖患者血清CRP水平明显高于非肥胖者 ,与SBP、TG、HOMA IR呈正相关 ,提示肥胖患者血清CRP水平升高与代谢综合征、胰岛素抵抗有密切关系 ;( 2 )血清CRP水平与P/I也呈正相关 ,提示血清CRP升高与 β 细胞功能缺陷可能也有一定关系 ;( 3 )BMI、WHR。

Purpose: To O assess the association of serum C-reactive protein (CRP), a sensitive systemic marker of inflammation, with metabolic syndrome in obese subjects. Methods: We studied 153 obese subjects and 47 normal control subjects in Shanghai area. Obese subjects are divided into two groups according to the degree of their glucose tolerance. Their serum CRP level and anthropometrical parameters, plasm glucose, lipid, fast insulin(FIN), proinsulin(PI) were measured. We tested whether serum CRP level are associated with metabolic syndrome in obesity. Results: (1) The obese subjects had higher serum CRP level than normal controls(P<0.001), there was no significant different between the obese subjects and the obese subjects with impairment of glucose metabolism (P = 0. 413); (2) There was significant positive correlation between serum CRP and W, WHR, SBP, TG, PI, P/I Ratio, HOMA-IR; (3) After adjusted AGE and BMI, there was positive correlation between CRP and SBP, WHR, PI yet, the correlation between serum CRP and other parameters disappeared. Conclusions: (1) There was significant increase of serum CRP level in obesity. Increase of serum CRP was closely correlation with metabolic syndrome; (2) β-cell impairment was possiblely association to increase of serum CRP; (3) BMI, SBP, WHR and PI were main factors relation to increase of serum CRP.