超选择靶区动脉置泵综合治疗晚期胃肠道肿瘤

Super-selective pump -insertion into the target artery and regional intraarterial infusion chemotherapeutant and immunizator in treatment of the latter gastrointestinal cancer

目的 评价术中超选择靶区动脉内置泵 ,术后皮下泵内区域灌注化疗药物及免疫制剂治疗晚期胃肠道肿瘤的疗效。方法 随访观察 88例手术证实不能切除的晚期胃肠道肿瘤患者 ,经术中选择性肿瘤供血动脉内置泵 ,术后泵内灌注化疗药物及免疫制剂后的疗效。其中胃癌 4 5例 ,直肠癌 3 1例 ,结肠癌 12例。结果 化疗后 ,完全缓解者 2例 ;部分缓解者 77例 ,其中 11例行二次根治性癌肿切除术 ;稳定者 9例 ;无 1例恶化者。治疗有效率 89.8% ( 79/ 88)。置泵术后生存满 1、2、3年者分别为 86 4 % ( 76/ 88)、3 0 7% ( 2 7/ 88)、10 2 % ( 9/ 88) ,平均生存期为 2 1 5个月。结论 术中超选择靶区动脉置泵 ,术后泵内灌注化疗药物及免疫制剂是治疗晚期胃肠道肿瘤的有效方法 ,可以延长患者的生存期 。

Objective To evaluate the effect of operative selective pump insertion into the tumorous target artery, postoperative regional infusion chemotherapeutant and immunizator for treatment the latter gastrointestinal cancer. Methods The effect of operative super selective pump insertion into the tumorous nutritious artery, postoperative regional infusion chemotherapeutant and immunizator for treatment 88 cases patients suffering from irremovable gastrointestinal cancer was observed.Of them,45 cases were gastric cancer,31 cases were rectal cancer, 11cases were colic cancer. Results Complete response 2 case; Part response 77 cases, 11 cases patients had received secondary resection after intraarterial chemotherapy. Non chang 9 cases;effective rates reach to 89 8%. One, two and three years survival rates were 86 4%?30 7% and 10 2%.Average survival period were 21 5 mouths. Conclusion Super selective pump insertion into the artery and regional intraarterial chemotherapy is an efficient way in treatment of the latter gastrointestinal cancer, which can delay the survival period of patients with tumor, and increase the resectable rate.