血浆神经肽Y浓度在慢性肾功能衰竭中的变化及其意义

The changes of plasma concentration of neuropeptide Y in patients with chronic renal failure

目的 为了探讨血浆神经肽Y(NPY)浓度在慢性肾功能衰竭中的变化。方法 我们对 10例慢性肾功能衰竭 (非血透者 ) ,12例终末期肾病规律血透前后及 11例健康人 ,采用放免法检测血浆中NPY的水平。结果 慢性肾功能衰竭患者血浆NPY浓度明显高于正常对照组 (P <0 .0 5 ) ,规律血透组比非血透组略高 ,但二者无显著差异 (P >0 .0 5 )。血透后血浆NPY浓度明显升高 (P <0 .0 1)。结论 慢性肾功能衰竭患者血浆NPY浓度升高 ,可能是导致终末期肾衰的因素之一。

Objective To investigate the changes of plasma concentration of neuropeptide Y(NPY)in patients with chronic renal failure(CRE).Method We measured plasma concentrations of NPY of 22 patients with CRF(ten without hemodialysis,12 with hemodialysis) with radioimmunoassay and compared them with those in 11 normal controls.Result The plasma concentration of NPY was higher evidently in CRF patients(without hemodialysis)than in healthy controls(P<0.05).Neuropeptide Y increased significantly after hemodialysis than before it in patients(P<0.01).No significant changes in NPY concentrations were found between performing hemodialysis and not performing hemodialysis in patients.Conclusion The plasma concentrations of NPY are elevated in CRF patients and accelerate the development from starting CRF to end stage renal disease(ESRD).