严重烧伤患者血清肌钙蛋白T变化分析

Analysis of alteration of serum troponin T in burned patients

目的 了解烧伤患者的血清肌钙蛋白T(TnT)水平 ,以明确TnT测定对烧伤后心肌损伤诊断的价值。方法 采用链霉亲合素预包被的双位点夹心ELISA法测定 75例烧伤患者血清TnT水平并与患者伤后血清心肌酶水平比较。结果 TnT在重度烧伤组为 ( 0 ..5 39± 0 .0 16 )ng/ml阳性率为 5 2 .0 % ;中度烧伤组为 ( 0 .0 8± 0 .0 7)ng/ml ,阳性率为 14 .2 % ;电烧伤组为 ( 0 .6 7± 0 .47)ng/ml ,阳性率为 45 .5 %。表明烧伤后血清TnT升高水平及阳性率与烧伤面积有关 ,且多数病人血清TnT水平在 48h内升高。结论 烧伤患者早期即存在心肌损伤 ,血清TnT测定对于烧伤后心肌损伤诊断的特异性明显优于心肌酶。

Objective To observe the level of troponin T(TnT)of burned patients for evaluating the diagnostic value of TnT in myocardial injury in burned patients.Method ELISA was adopted to detect serum TnT in 75 burned patients.The serum TnT levels were compared with the levels of serum myocardial enzymes.Results The serum TnT levels of patients in severe burn group,moderate burn group and electric burn group were 0.539±0.46 ng/ml,0.08±0.07 ng/ml and 0.67±0.47 ng/ml respectively.Their positive rates were 52.0%,14.2% and 45.5% respectively.It made clear that the serum TnT levels and positive rates were related to burn size,and most burned patients' TnT levels increased in 48 h.Conclusion Burned patients had mycoardial injury in early stage of burn.Specificity of serum TnT used for diagnosing the myocardial injury was higher than the index of serum enzymes in burned patients.