阿米洛利对大鼠心肌肥厚和主动脉反应性的作用

The Effects of Amiloride on the Hypertrophic Atrium and Aortal Reactivity in Rats

目的 :观察阿米洛利 (Ami)对甲状腺素 (Thy)所致大鼠心肌肥厚和主动脉反应性的作用。方法 :大鼠腹腔注射Thy造成心肌肥厚模型后 ,用形态学和离体实验方法研究Ami对肥厚心肌和主动脉的作用。结果 :Ami能改善肥厚心肌的形态 ,降低血管平滑肌对去甲肾上腺素 (NA)的反应性 ,抑制左心房收缩力及轻度减慢右房频率 ,能使NA的量效曲线右移 ,最大反应压低。结论 :阿米洛利能抑制Thy引起的心肌肥厚 。

Objective:To observe the effects of amiloride on the hypertrophic atrium and aortal reactivity in rats. Methods:The hypertrophy of atrium and thoracic aorta in rats was induced by administration of thyroxine through intraperitoneal injection. The effects of amiloride on the hypertrophic atrium and thoracic aorta were observed with morphological and biomechanical experiments in three randomly allocated groups of rats (The control group, hypertrophy group and the treatment group). Results:The morphological changes were improved in the treatment group. The responsiveness of the smooth muscle of the aorta and muscle strength of the left atrium as well as the contraction frequency of the right atrium were inhibited in those treated with amiloride. The dose effects curve was moved to the right and the maximum response decreased by the administration of amiloride. Conclusion:Amiloride can inhibit the hypertrophy of rat atrium and aortal reactivity.