欣得康对晚期胃癌细胞凋亡的影响

The Effects of Xindekang on Apoptosis of Advanced Stage Stomach Cancers

目的 :研究欣得康诱导胃癌细胞的凋亡作用。方法 :选择晚期胃癌患者 5 9例 ,随机分为治疗组 30例 ,化疗同时给予欣得康口服 ;对照组 2 9例 ,仅给予化疗。疗程结束后 ,观察欣得康临床疗效及细胞凋亡指数变化 ,比较两组病理组织学的改变。结果 :治疗组总有效率 5 0 .0 % ,对照组 2 4.1% (P <0 .0 5 ) ;治疗组治疗前后胃癌细胞凋亡指数分别为 ( 5 .8± 3 .5 ) %和 ( 31.7± 12 .8) % (P <0 .0 5 ) ,对照组分别为 ( 5 .2± 3 .8) %和 ( 12 .3± 6 .1) % (P <0 .0 5 )。两组治疗后胃癌细胞凋亡指数比较差异有显著性 (P <0 .0 5 )。治疗组肿瘤组织学改变较对照组明显 (P <0 .0 5 )。结论 :欣得康治疗晚期胃癌有效。

Objective:To study the effects of Xindekang on apoptosis of advanced stage stomach cancer. Methods: 30 patients with advanced stage stomach cancer in the test group were treated by oral intake of Xindekang plus chemotherapy, and 29 in the control group by chemotherapy alone. Results:The effective rate in the test group (50%) was higher than that in the control group (24.1%, P<0.05). The tumor apoptosis indices before and after treatment in the test group and the control group were 5.8%± 3.5% vs 31.7%±12.8% (P<0.05) and 5.2%±3.8% vs 12.3%±6.1% (P<0.05), respectively. The tumor apoptosis index after treatment in the test group increased to a larger extend than that in the control group (P<0.05). The changes of tumor tissue in the test group were more obvious than that in the control group (P<0.05). Conclusions: Xindekang has significant effects in the treatment of advanced stage stomach cancer. It was speculated that one of the mechanisms of the effects was that it can induce tumor apoptosis.