普萘洛尔治疗烧伤后窦性心动过速42例

Observation of Propranolol on 42 Cases of Sinus Tachycardia in Patients with Burns

目的 :观察普萘洛尔治疗烧伤后窦性心动过速疗效及对心肌抑制作用。方法 :烧伤休克纠正后口服普萘洛尔 ,根据心率、血压变化情况调整剂量 ,使成人心率控制在 <12 0次·min 1 ,儿童心率 <14 0次·min 1 ,最佳治疗量维持 1～ 2周。随时监测血压、心率变化。结果 :治疗前后平均心率下降 ( 4 2 .37± 6 .42 )次·min 1 ,治疗前后血压无明显变化。结论 :治疗量普萘洛尔对心肌有保护作用 ,不足以引起心肌抑制 。

Objective:To observe the effect of propranolol on sinus tachycardia after burns and its role in myocardial depression. Methods:When the shock caused by burns was corrected, propranolol was taken orally with a low dosage of 5 mg, 3 time per day for adults and 0.1 mg·kg 1 , 3 times per day for children. In order to maintain the heart rate of the adults below 120 min 1 and that of the children below 140 min 1 , the dosage was adjusted according to the changes of heart rate and blood pressure. The optimal dosage of prapronolol was maintained for one to two weeks, and then reduced to half of it for about one week till the end of the treatment. The changes of the blood pressure and the heart rate were monitored dynamically. Results:The average decrease of heart rate after treatment was 42.37±6.42/ min compared to that before the treatment. No significant change in the blood pressure was observed after treatment. Conclusion:The treatment dosage of propranolol was protective to the myocardium and did not cause significant myocardial inhibition. Therefore, it can be used as a routine treatment for sinus tachycardia after burns.