癌基因水平对上颌窦癌临床行为的初步研究

The preliminary research of maxillary sinus cancer on oncogene level

目的 :探讨癌基因c myc、bcl 2蛋白产物在上颌窦癌中的表达情况及其临床意义。方法 :采用免疫组织化学方法 ,对 4 6例上颌窦癌及 5 6例正常鼻粘膜组织中癌基因c myc、bcl 2蛋白产物进行检测。 结果 :正常鼻粘膜鳞状上皮细胞中癌基因c myc、bcl 2蛋白阳性率为 0 ;上颌窦癌细胞中 ,癌基因c myc、bcl 2蛋白阳性率分别为 73.91% (34/46 )、6 0 .87% (2 8/46 )。复发组c myc蛋白的阳性率 (91.6 7% )显著高于未复发组 (6 7.6 5 % ) ,P<0 .0 1;复发组bcl 2蛋白的阳性率 (5 0 .0 % )明显低于未复发组 (6 4 .71% ) ,P <0 .0 5。c myc蛋白阳性率随临床分期的增加而升高 ,其中Ⅳ期阳性率 (88.89% )明显高于Ⅱ期 (6 3.6 4 % ) ,P <0 .0 5 ;bcl 2蛋白阳性率随临床分期的增加而下降 ,Ⅳ期阳性率 (5 5 .5 6 % )明显低于Ⅱ期 (72 .73% ) ,P <0 .0 5。bcl 2蛋白的阳性率随原发癌病理分级的降低而下降 ,低分化组 (5 6 .2 5 % )明显低于高分化组 (71.4 3% )和中分化组 (6 2 .5 0 % ) ,P <0 .0 1和 0 .0 5 ;中分化组 (6 2 .5 0 % )亦明显低于高分化组 (71.4 3% ) ,P <0 .0 5 ;p6 2 c myc的阳性率与原发癌病理分级无明显关系。结论 :c myc、bcl 2基因参与了上颌窦的癌变及发展过程 。

Objective:To determine the oncogene c myc,bcl 2′ product expression in the maxillary sinus cancer and to investigate its clinical significance.Method:In 46 maxillary sinus cancer and 56 normal nasal mucous membrane,immunochemical method was adopted to determine oncogene c myc and bcl 2′ product.Result:In the normal nasal mucous membrane,the positive rates of oncogene c myc and bcl 2′ product were 0;in the maxillary sinus cancer,the positive rates of c myc and bcl 2′ product were 73.91 (34/46), 60.87 (28/46)respectively.The positive rate of c myc′ product in the relapse group( 91.67 %,11/12) was significantly higher than that in the non relapse group( 67.65 %,23/34),P< 0.01 ;the positive rate of bcl 2′ product in the relapse group(50%,6/12) was significantly lower than that in the non relapse group( 64.71 %,22/34),P< 0.05 ;the positive rate of c myc′ product in the stage Ⅳ( 88.89 %,8/9) was significantly higher than that in the stage Ⅱ ( 63.64 %,7/11),P< 0.05 ;the positive rate of bcl 2′ product in the stage Ⅱ( 72.73 %,8/11) was significantly higher than that in the stage Ⅳ( 55.56 %,5/9),P< 0.05 ;the positive rate of bcl 2′ product was in the negative correlation to the pathological grade of primary carcinoma.Conclusion:The oncogene c myc and bcl 2 take part in the genesis and advancing course of maxillary sinus cancer.Their products were the important oncogology indexes,which might be useful to determine illness condition and predict relapse.