细胞因子活性与小儿肺炎关系的探讨

Relationship Between Cytoleukins Activity and the Mechanism of the Infants Pneumonia

目的 :探讨小儿肺炎的发病及病情变化与细胞因子活性的关系。方法 :采用化学发光酶免疫分析法检测 47例肺炎患儿 (其中单纯性肺炎 40例 ,重症肺炎 7例 )及 40例正常健康儿童血清白细胞介素 1β(interleukin 1β ,IL 1β)、白细胞介素 8(interleukin 8,IL 8)和肿瘤坏死因子α(tumornecrosisfactor α ,TNFα)的水平。 结果 :入院第 1天肺炎患儿血清IL 8、TNFα含量高于正常健康儿童 (P <0 .0 1) ,重症肺炎组血清IL 8含量高于单纯性肺炎组 (P<0 .0 1)。治疗过程中 ,单纯性肺炎患儿随病情的减轻IL 8、TNFα含量逐渐下降 (P <0 .0 1) ;而重症肺炎患儿则随病情的加重IL 1β、IL 8和TNFα含量明显升高 ,与治疗前比差异显著 (P <0 .0 1)。结论 :血清IL 1β、IL 8和TNFα水平的变化与肺炎患儿病情的严重程度有关 ;连续检测血清IL 1β、IL

Objective: To investigate the relationship between the mechanism of the infants pneumonia and the cytoleukins activity such as IL 1β, IL 8 , and TNFα.Methods: Serum IL 1β , IL 8 , and TNFα were measured with chemiluminescent enzyme immunoassay in 47 infants with pneumonia and 40 healthy infants as controls . Seven severe pneumonia and 40 mild pneumonia were in the 47 cases.Results: The levels of serum IL 8 and TNFα in the pneumonia group were higher than those in the controls, and serum IL 8 in severe pneumonia group was higher than that in mild pneumonia group (P<0.01). During the treatment, the levels of IL 8 and TNFα of 40 infants with mild pneumonia decreased significantly with the improvement of symptoms ; however, contents of serum IL 1β, IL 8, and TNFα of 7 infants with severe pneumonia increased significantly with the worsening of the ill (P<0.01). Conclusion: The variation of the serum IL 1β, IL 8, and TNFα is related with the state of illness of infants pneumonia. The serum levels of IL 1β, IL 8, and TNFα are worth in evaluating the tendancy and prognosis of the pneumonia.