对氯对甲氧基苯乙酮缩氨基硫脲合铜(Ⅱ)配合物的合成表征及其抗癌活性

Study on the Copper Complexes of p-cholro p-methoxyacetophenone thiosemicar- bazone and their anticancer activities

目的 合成和表征对氯、对甲氧基苯乙酮缩氨基硫脲与铜 (Ⅱ )形成的 4个配合物 ,并观察其中 2个配合物的体内、外抗癌活性。方法 配体和配合物的合成参照文献[1、2 ] ,采用元素分析、摩尔电导和红外光谱对这些配合物进行表征。用胎盘兰染色法测定 2个配合物对S180 腹水癌细胞的体外抗癌活性 ,采用小鼠移植性肿瘤模型观察其体内抗癌作用。结果 2个配体与铜 (Ⅱ )形成的 4个配合物均是以亚胺基N原子和S原子为配位的二齿配合物。其中 2个配合物对氯苯乙酮缩氨基硫脲合铜 (Ⅱ )和对甲氧基苯乙酮缩氨基硫脲合铜 (Ⅱ )具有较好的体内、外抗癌活性。结论 铜 (Ⅱ )

Aim We synthesized and characterized four copper(Ⅱ) complexes of p-cholro,p-methoxyacetophenone thiosemicarbazone and investigated the anticancer activities of two of them both in vitro and in vivo.Methods According to literature 1 and 2 we synthesized the four copper(Ⅱ) complexes of p cholro,p methoxyacetophenone thiosemicarbazone and then characterized by elemental analysis,molar conductivity and infrared spectrum.The in vitro anticancer activities on S 180 Erlich cells were studied by using placenta blue method.Their in vivo anticancer activities were studied by using transplant S 180 tumor cells on rats.Results The results show that the ligands may coordinate with copper ions through the imide N and S atoms,two copper complexes of p-chdro,p-methoxyacetophenone thiosemicavbazone have a good anticancer activities both in vitro and in vivo.Conclusion The copper(Ⅱ) complexes of thiosemicarbazone should make deeply study as an anticancer drug.