盐酸氯胺酮控释片的研制

Study of the Controlled-release Ketamine Hydrochloride Tablets

目的 为延长盐酸氯胺酮的作用时间 ,便于给药 ,制成盐酸氯胺酮控释片。方法 以HPMC(羟丙基甲基纤维素 )及Carbopol 934p(卡泊姆 )为辅料 ,制成胃内漂浮片并进行体外累积释放度测定。结果 体外释药基本达到零级释放过程 ,r=0 .940 4,体外释药量与释药时间具有良好的相关性。Peppas方程中n值为 0 .5 10 9,控释片中药物的释放机制是亲水凝胶层扩散和骨架溶蚀。结论 盐酸氯胺酮控释片达到了设计的要求 ,5min内体外释药约为标示量的 10 %左右 ,6h后释药约 90

Aim To prepare the controlled-release ketamine hydrochloride tablets for the delayed-action time and convenience taken by patients.Methods To prepare the prolonged tablet in stomach with HPMC and Carbopol 934p as excipients.The release rate of the controlled-release ketamine hydrochloride tablets were determined by HPLC in vitro.Results The drug release rate from the controlled-release ketamine hydrochloride tablet was of zero-order release.There was a good linear correlation between the release rate and time (r=0.940 4).The n value in Peppas equation was 0.510 9.The drug-release mechanism is passive diffusion and frame corrosion of hydrophilic matrix.Conclusion The study about the sustained-release ketamine hydrochloride tablet achieved the goal of design.The release rate of the sustained-release tablets was 10% in 5 minutes,and 90% in 6 hours in vitro.