三七消痔栓的鉴别及人参皂苷R_(g1)的含量测定

Determination of the content of Ginsenoside R_(gl) in Sanqi Xiaozhi Suppositories by TLC scanning method

目的 对三七消痔栓进行质量控制 ,对其主要药物进行定性鉴别 ,并建立人参皂苷Rg1的定量测定办法。方法 采用TLC法对三七、川芎、冰片进行定性鉴别 ,用薄层双波长锯齿扫描法测定人参皂苷Rgl的含量。结果 三七消痔栓中人参皂苷Rg1在 0 .798～ 3.990 μg (r =0 .9989)范围内呈良好的线性关系 ,含量为 0 .194mg·g-1,回收率为 98.2 8%RSD为 0 .6 6 %。结论 TCL法作为该制剂的质量控制方法 ,简单快速 。

Aim To control the quality of Sanqi Xiaozhi Suppositories(Sanqi XZ).Methods Sanqi,Chuanxiong and borneol were identified by TLC method. The content of Ginsenoside R gl in Sanqi XZ was determined by dural wavelength saw-tooth TLC-scanning method. Results The content of Ginsenoside R gl was 0.194mg·g -1 and recovery rate was 98.28%. Conclusion The method in this article is stable and reliable,simple and rapid,which can be used as the index of quality control.