基线血脂水平与调脂药调脂幅度的关系

Relationship between baseline blood lipids and reduction of blood lipids after atorvastatin and simvastatin therapy

目的 :观察不同基线血脂水平患者对同剂量阿托伐他汀和辛伐他汀治疗的反应。方法 :不同基线总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)、甘油三酯 (TG)及高密度脂蛋白胆固醇 (HDL C)水平患者给予同剂量的阿托伐他汀和辛伐他汀 (均为 10mg/d)治疗 8周 ,观察其血脂降低的绝对幅度和相对幅度。 结果 :①随着TC基线增高 ,两种他汀类药物降低TC的绝对幅度增加 ,而相对幅度增加不明显 ;②随着基线LDL C和TG增高 ,治疗后LDL C和TG降低的绝对幅度和相对幅度均明显增加 ;③基线HDL C低于正常者 ,治疗后HDL C明显增加 ,而基线HDL C正常者 ,治疗后HDL C改变不明显或甚至反有轻微降低。结论 :基线血脂水平可能明显影响调脂疗效 ;在进行调脂治疗研究时 ,要考虑到基线血脂水平。

Objective:To observe the responses of different baseline blood lipids to same dosage of atorvastatin and simvastatin.Methods:Patients with different baseline of TC,LDL C,TG and HDL C were given same dose (10 mg/d)of atorvastatin or simvastatin for 8 weeks, and the absolute and relative (%) reduction of blood lipids were recorded.Results:①With increases of baseline TC level, the absolute reduction of TC was increased for both statins, while no marked increase of relative reduction was observed;②With increases of baseline LDL C and TG, the absolute and relative reduction of LDL C and TG all were significantly increased after therapy;③The HDL C markedly increased after therapy in cases with baseline HDL C lower than that of normal,while no significant change or even mild reduction of HDL C was found in cases with normal HDL C baseline.Conclusion:The baseline lipids level might significantly affect the efficacy of lipid therapy and baseline lipid level should be considered in studying hyperlipidemia therapy.