无创血管内皮舒张功能与冠心病的关联性

The relation between non-invasive detectin of endothelium-dependent relaxing function and coronary heart disease

目的 :探讨无创血管内皮舒张功能与冠心病的关联性。方法 :经冠状动脉造影证实的冠心病患者 3 0例 ,分为冠心病 组 17例 ,冠心病 组 13例。对照组 2 0例 ,为健康查体者。肱动脉内皮依赖性舒张功能测定用无创高分辨超声法。结果 :13组基础血管内径无差异。 2反应性充血后肱动脉内径变化百分数 ,冠心病 组 ( 11± 4 ) %、冠心病 组 ( 6± 2 ) % ,对照组 ( 16± 5 ) % ,3组间差异显著 ( vs P<0 .0 1; , vs对照组均 P<0 .0 1)。 3含化硝酸甘油后肱动脉内径变化百分数 ,冠心病 组 ( 17± 5 ) %、冠心病 组 ( 14± 3 ) % ,对照组 ( 2 5± 7) % , 组 , 组与对照组比较差异显著 (均 P<0 .0 1) ; 组与 组间无显著差异。结论

AIM:To explorate the relation between endothelium dependent relaxing function and coronary heart disease (CHD). METHODS:Thirty cases with CHD confirmed by coronary angiography were classified as two groups,CHD Grpup Ⅰ with 17 cases and CHD Group Ⅱ with 13 cases. 20 healthy individuals served as the control group. Brachial endothelium dependent relaxing function was detected by high resolution ultrasound. RESULTS:① No difference was detected in the basic diameters of the brachial arteries of the three groups. ②Flow mediated dilatation of the brachial arteries in the three groups were (11±4)%,(6±2)%,(16±5)% respectively. There were significant differences among three groups (Ⅰ vs Ⅱ P <0.01,Ⅰ,Ⅱ vs the control group both P <0.01). ③The vasodilatadion responses to nitroglycerin in the CHD groups [Ⅰ (17±5)%,Ⅱ (14±3)%] was significantly different comparied with that of the control group (25±7)% (both P <0.01). But there was no significant change between CHD Group Ⅰ and CHD Group Ⅱ. CONCLUSION:There exists a relation between endothlium dependent relaxing function detected by high resolution ultrasound and the severity of AS in patients with CHD.