摘要
目的:探讨鞘内注射甲氨蝶呤和地塞米松治疗狼疮脑病的疗效。方法:选择14例住院的系统性红斑狼疮病人,临床上具有精神和神经异常表现,脑脊液检查、头颅CT 异常表现的狼疮脑病,在常规剂量糖皮质激素治疗狼疮脑病不能缓解的情况下鞘内注射甲氨蝶呤和地塞米松。结果:14例病人都得到了不同程度的缓解 结果:鞘内注射甲氨蝶呤和地塞米松是治疗狼疮脑病的一种安全而有效的方法,值得进一步的临床研究。
Objective: The effect of intrathecal injections with methotrexate and dexamethasone wasassessed on encephalopathy of systemic lupus erythematosus (CNS-SLE). Methods: Intrathecal injec- tions with methotrexate and dexamethasone were administered to 14 inpatients with CNS-SLE, of whichCNS-SLE was diagnosed through abnormal psychonervous manifestations, cerebrospinal fluild test and CTof head and of which CNS-SLE could not be improved with routine dose of glucocorticoid. Results: Four-teen patients with different CNS-SLE manifestations attained a good response after therapy with intrathecalinjections with methotrexate and dexamethasone. Conclusion: This clinical observation shows that in-trathecal injections with methotrexate and dexamethasone appear to be safe and effective for the manage-ment of CNS-SLE. This therapy should be studied continuously.
