原发性肝癌P73、P53蛋白表达的检测及临床意义

EXPRESSION OF P73?P53 AND ITS RELATION TO CLINICAL SIGNIFICANCE IN HEPATOCELLULAR CARCINOMA

目的 了解 P73在原发性肝癌中是否有表达 ,以及 P5 3与 P73之间可能存在的关系。方法 通过免疫组织化学方法 ,对 31例手术切除的原发性肝癌组织标本进行了检测。并分析了表达结果与 Edmondson肝癌分级的关系。结果 16例( 5 1.6 % )肝癌组织突变型 P5 3为阳性 ,而 P73无 1例阳性。P5 3的表达情况与 Edmondson分级有显著相关性。结论 突变型P5 3阳性肝癌患者比阴性患者有更差的预后。

Objective To investigate the expression of P53 and P73 protein in the tissue of HCC,to determine whether P73 protein expression in HCC and the possible association of P73 with P53.Methods Immunohistochemistry were performed in tissues from 31 patients with resected HCC.The results obtained were analyzed with Edmondson grade.Results By immunohischemistry,mutated P53 protein was detected in 16(51.4%) cases and no P73 protein expression was observed.P53 expression status was statistically significantly related to Edmondson grade,Conclusion Patients with P53-positive tumors have poorer prognosis than those with P53-negative carcinomas.There are no P73 expression in hepatocellular carcinoma.