摘要
目的 :比较不同吸氧流量减轻急性心肌梗死 (AMI)缺氧性损伤的效果。方法 :在 32只家兔AMI动物模型中 ,经气管插管吸入 10 0 %浓度氧气 ,比较 0、0 .8、1.2和 1.8L/min 4种吸氧流量对AMI的作用。吸氧效应指标以动脉血氧分压 (PaO2 )和氧饱和度 (SaO2 )表示 ;心肌损伤指标有心电图、心肌酶和心脏病理学检查。结果 :①动物形成AMI模型后PaO2 和SaO2 下降。②心肌损伤程度与PaO2 和SaO2 降低有关。③吸氧能增加AMI动物PaO2 和SaO2 水平。④SaO2 ≥ 95 %的AMI动物心肌损伤程度较轻。结论 :根据AMI缺氧具体情况选择吸氧流量 ,确保SaO2 ≥ 95 %有助于减轻心肌损伤。
Objective: To investigate the effect of oxygen inhalation on reducing myocardial injury in the acute myocardial infarction(AMI)rabbits. Methods: An animal model of AMI was created in 32 rabbits by ligation of the left anterior descending coronary artery(LAD). The results of arterial blood oxygen saturation(SaO 2) and pressure(PaO 2), electrocardiograme, myocardial enzyme and pathological changes were evaluated after 100% oxygen inhalation in flow of 0, 0.8,1.2 and 1.8 liter/min. Results:①SaO 2 and PaO 2 were descended apparently after AMI. ② The degree of myocardial injury was related with decrease of SaO 2 and PaO 2.③ SaO 2 and PaO 2 were elevated in animals with AMI after supplemental oxygen.④The degree of myocardial injury in SaO 2≥95% was significantly lower than that in SaO 2<95%. Conclusion: According to degree of hypoxaemia, SaO 2≥95% was gained by oxygen inhalation to aid reduction of myocardial injury.
出处
《中华护理杂志》
CSCD
北大核心
2002年第1期9-11,共3页
Chinese Journal of Nursing
基金
徐州市科委基金资助课题项目 ( 970 2 6 )
