山东省1995至2000年山东省肾综合征出血热监测分析

Surveillance and Analysis on HFRS in Shandong Province from 1995 to 2000

目的 通过监测分析 ,掌握全省肾综合征出血热 (HFRS)流行规律 ,控制暴发流行 ,进一步降低发病率 ,制订防制措施。方法 采用直接免疫荧光法 (FAT)检测鼠肺HV抗原 ;采用间接免疫荧光法 (IFAT)检测HFRS病人、健康人血清。结果 1995～ 2 0 0 0年全省共发病 96 188例 ,年均发病率为 18 36 /10万 ,死亡 345人 ,病死率为 0 36 %。病例仍主要分布在鲁中南山区和胶莱平原 ,鲁西北平原次之 ,鲁东南丘陵地区病例较少 ;全省 17个地市 137个县有病例报告 ,以鲁中南山区和胶莱平原的临沂、日照、济南、淄博和潍坊 5市发病最多 ,占全省病例总数的 6 2 2 4 %。宿主动物野外以褐家鼠和黑线姬鼠为优势种 ,分别占 4 0 4 4 %和 33 75 % ;室内以褐家鼠为优势种 ,占 82 0 8%。结论 进一步加大监测力度及接种HFRS疫苗 。

Objective To grasp HFRS's prevalent regularity in whole province, to control its outbreak and to work out the way to deal with it.Methods To use direct fluorescent antibody technic (FAT) to test HV antigen in rat's lung, use indirect fluorescent antibody technic (TFAT) and Mac ELTSA to test HV antibody in serum of patient and people in good health.Results There were 96 188 patients in whole province from 1995 to 2000, and 345 of them died. The average morbidity was 18.38 per 100 000 persons and mortality was 0.36 percent. Most patients were in the middle-south hilly land and Jiaolai plain of Shandong province.One hundred and thirty six conuties of 17 cities of Shandong province had patients. The patients were both disperse and relatively concentrately.Sixty one point seventy three percent of patients came from Linyi?Rizhao?Jinan?Taian and Zibo city.Most HFRS's host animal in field was Apodemus agrarius Pallas and Rattus norvegicus Berkenhout , most host animal in the house was Rattus norvegicus Berkenhout.Conclusion HFRS's surveillance and vaccinating people with HFRS's vaccine must be enhanced.