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传递体作为双氯芬酸钠经皮渗透载体的研究 被引量:7

A Study of Transfersomes as a Transdermal Penetration Carrier for Diclofenac Sodium
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摘要 目的 :研制双氯芬酸钠传递体 ,进行初步临床研究。方法 :通过实验筛选该传递体的处方工艺 ,对其性状、包封率、稳定性、体外透皮及初步临床进行实验。结果 :制得的传递体为乳白色混悬液 ,平均粒径 81 .50nm ;平均包封率 73 .1 2 % ;2 4h时药物累积透皮吸收百分率 58.62 % ,药物滞留在皮内的百分率 2 2 .61 % ;临床应用中实验组与对照组双氯芬酸凝胶的疗效相当 ,不良反应发生率低。结论 :双氯芬酸钠传递体有望成为适于临床给药的一种新剂型。 Objective: To prepare transfersomes for diclofenac sodium and to make a prelimioary study of their clinical application. Methods:The formula technologies of the transfersomes were screened experimentally. A study of the property, embedding ratio, stability, in vitro transdermal penetration and preliminary clinical application of the transfersomes was made. Results:The transfersomes prepared were a cream white suspension, with a mean particle diameter of 81.5nm and a mean embedding ratio of 73.12% . A sum total of 58.62% of the diclofenac sodium tranfersomes was transdermally absorbed in 24 hours while the amount of the transfersomes detained in the skin in the same period of time accounted for 22.61% of the total. The clinical curative effects of the preparation were similar to those seen in control patients treated with diclofenac sodium gel. The incidence of adverse reaction, however, was lower in patients subjected to transfersomes treatment. Conclusion:The preparation diclofenac sodium transfersomes is expected to become a new dosage form for clinical application.
出处 《医药导报》 CAS 2002年第1期17-18,共2页 Herald of Medicine
关键词 双氯芬酸钠 传递体 制备 经皮渗透载体 Diclofenac sodium Transfersomes preparation Clinical application
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