扩张型心肌病发病机制的研究进展

Progress of pathogenesis in dilated cardiomyopathy

扩张型心肌病 (DCM )以左心室或双心室扩张并伴收缩功能受损为特征 ,其发病机制主要与病毒感染后的自身免疫反应有关。 80年代以后 ,遗传因素与DCM的关系逐渐受到重视 ,分子生物学技术的发展促进了这方面的研究。本文就DCM的免疫学和遗传学两方面的研究进展作一简要综述。

Dilated cardiomyopathy is characterized by the dilatation of left ventricle or biventricle accompanied by the impairment of the contractile force. The pathogenesis is concerned to have some connection with autoimmunity after infection for virus. Later of 1980's, it is more and more taken seriously that the relationship between genetics and dilated cardiomyopathy, and is stimulated by the development of molecular biological technique. We will summarize the progress of pathogenesis in dilated caediomyopathy for immunology and genetics.