脑梗塞患者PAgT及双侧颈内动脉狭窄程度的变化

Variations of Platelet Aggregation Rate and Internal Carotid Artery Stenosis in Patients with Cerebral Infarction

目的探讨血小板聚集率及颈内动脉狭窄与脑梗塞发病的关系。 方法测定 12 0例急性脑梗塞患者及 6 0例正常人的血小板聚集率 (1、5min ,MAR) ,B型多谱勒超声断层扫描检测颅外段颈内动脉狭窄程度。 结果脑梗塞组的血PAgT 1min与正常对照组比较有显著差异 (P <0 .0 5 ) ,PAgT 5min、MAR与对照组比较有非常显著差异(P <0 .0 1) ,脑梗塞组B超检测颈内动脉中度以上狭窄占 6 2 .5 % ,正常对照组中度以上狭窄占 35 % ,两组比较有非常显著差异 (P <0 .0 0 5 )。 结论血小板聚集率升高及颅外段颈内动脉中度以上狭窄 ,与脑梗塞密切相关。

Objective To observe relationship between platelet aggregation rate, internal carotid artery stenosis and occurrence of cerebral infarction. Methods The platelet aggregation test (PAgT 1min, PAgT 5min, MAR)and levels of the external cervical segment of internal carotid artery stenosis detected by B type ultrasonic tomographic scanning were performed in 120 cases of cerebral infarction patients and 60 normal controls. Results There was significant difference between patients and controls in the PAgT 1min (P< 0.05). The differences of PAgT 5min and MAR between the two groups were very significant ( P<0.01 ). The occurrence rate of internal carotid stenosis above the mediate level is 62.5% while the rate is 35% in the controls. There was very significant difference between these two groups ( P < 0.005). Conclusion The increase of platelet aggregation rate and stenosis of the external cervical segment of the internal carotid artery above the mediate level are related to the occurrence of cerebral infarction.