间接免疫荧光法检测肺炎衣原体抗体的临床意义

Determination of Antibodies against Chlamydia Pneumoniae by Indirect Immunofluorescence Test

本文采用间接免疫荧光试验 ,对 132例 (呼吸系统感染性疾病、冠心病和心肌梗塞 )患者和 40名正常人的血清进行了Cpn特异性IgG、IgA和IgM抗体的检测 ,以研究Cpn感染的状况和探讨检测Cpn抗体的临床意义。结果 :观察组CpnIgG抗体阳性率虽高于对照组 ,但无显著性差异 (P >0 0 5 ) ;观察组GMT明显高于对照组 (P <0 0 5或P <0 0 1) ;呼吸系统感染性疾病的CpnIgA抗体阳性率显著高于对照组 (P <0 0 5 )。因此 ,测定Cpn抗体滴度有助于Cpn感染与疾病关系的研究。

The specific IgG,IgA and IgM antibodies were determined by means of indirect immunofluorescence test in 132 patients with respiratory diseases,coronary heart disease and myocardial infarction and 40 normal individuals as controls,in order to study the infectious status of C.pneumoniae infection and the clinical significance of these antibodies. It was found that there was no significant difference of the specific IgG antibodies both in observation group and the controls,but the geometric mean titres (GMT) of the specific IgG antibodies in the observation group were significantly higher than those of the controls. The positive rate of specific IgA antibodies in patients with respiratory infections was significantly higher than that of the controls. Thus,the determination of specific antibodies against C.pneumoniae would be helpful to the study of this infection.