期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MHC在异种移植中作用的研究进展 被引量：1

原文传递
导出
摘要 异种移植是解决供体移植器官缺乏的较好途径之一 ,但移植后的超急性、急性以及后续的各种免疫排斥反应限制了它的临床应用。目前关于异种移植排斥反应机制和种间耐受的研究非常活跃 ,本文从组织相容性抗原 (MHC )的抗原特性、T细胞发育识别及NK细胞效应等几方面对MHC在异种移植中作用的进展做了简要综述。
作者 韩红星 孔繁华 奚永志
机构地区 军事医学科学院附属医院免疫学研究室
出处 《上海免疫学杂志》 CSCD 北大核心 2002年第1期66-67,70,共3页 Shanghai Journal of Immunology
关键词 组织相容性复合体 异种移植 T细胞 NK细胞 移植免疫学
分类号 R392.4 [医药卫生—免疫学]
  • 相关文献

参考文献13

  • 1[1]Cozzi E,Masroor S,Soin B,et al.Progress in xenotransplantation [ J ].Clin Nephrol,2000,53:13
  • 2[2]Taylor CJ,Tang KG,Smith SI,et al.HLA-specific antibodies in highly sensitized patients can cause a positive crossmatch against pig lymphocytes[ J].Transplantation,1998,65:1634
  • 3[3]Saxton NE,Hallaway RV,Ladyman HM,et al.Anti-major histocompatibility complex class Ⅱ treatment prevents graft rejection in the hamsterto-rat cardiac xenograft[J].Transplantation,1999,67:1599
  • 4[4]Czech KA,Ryan JW,Sagen J,et al.The influence of xenotransplant immunogenicity and immunosuppression on host MHC expression in the rat CNS[J].Exp Neurol,1997,147:66
  • 5[5]Yun S,Gustafsson K,Fabre JW.Suppression of human anti-porcine Tcell immune responses by major histocompatibility complex class Ⅱ transactivator constructs lacking the amino terminal domain[J].Transplantation,1998,66:103
  • 6[6]Colson YL,Tripp RA,Doherty PC,et al.Antiviral cytotoxic activity across a species barrier in mixed xenogeneic chimeras:functional restriction to host MHC[J].J Immunol,1998,160:3790
  • 7[7]Nikolic B,Gardner JP,Scadden DT,et al.Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC[J].J Immunol,1999,162:3402
  • 8[8]Zhao Y,Swenson K,Sergio JJ,et al.Pig MHC mediates positive selection of mouse CD4+ T cells with a mouse MHC-restricted TCR in pig thymus grafts[J].J Immunol,1998,161:1320
  • 9[9]Chitilian HV,Laufer TM,Stenger K,et al.The strength of cell-mediated xenograft rejection in the mouse is due to the CD4+ indirect response[ J].Xenotransplantation,1998,5: 93
  • 10[10]Xu XC,Naziruddin B,Sasaki H,et al.Allele-specific and peptide-dependent recognition of swine leukocyte antigen class I by human cytotoxic T-cell clones[J].Transplantation,1999,68:473

同被引文献15

  • 1Luder CG,Lang C,Giraldo-Velasquez M,et al.Toxoplasma gondii inhibits MHC class Ⅱ expression in neural antigen-presenting cells by down-regulating the class Ⅱ transactivator CⅡTA[J].J Neuroimmunol,2003,134(1-2):12-24.
  • 2Basta PV,Sherman PA,Ting JP.Identification of an interferon-gamma response region 5' of the human histocompatibility leukocyte antigen DR alpha chain gene which is active in human glioblastoma multiforme lines[J].J Immunol,1987,138(4):1275-1280.
  • 3Duquesnoy RJ,Demetris AJ.Immunopathology of cardiac transplant rejection[J].Curr Opin Cardiol,1995,10(2):193-206.
  • 4Sundstrom JB,Ansari AA.Comparative study of the role of professional versus semiprofessional or nonprofessional antigen presenting cells in the rejection of vascularized organ allografts[J].Transpl Immunol,1995,3(4):273-289.
  • 5Campos L,Deli BC,Kern JH,et al.Survival of MHC deficient mouse heterotopic cardiac allografts and xenografts[J].Transplant Proc,1995,27(1):254-255.
  • 6Krieger NR,Yin DP,Fathman CG.CD4^+ but not CD8^+ cells are essential for allorejection[J].J Exp Med,1996,184(5):2013-2018.
  • 7Pietra BA,Wiseman A,Bolwerk A,et al.CD4 T cell-mediated cardiac allograft rejection requires donor but not host MHC class Ⅱ[J].J Clin Invest,2000,106(8):1003-1010.
  • 8Holling TM,van Der Stoep N,Quinten E,et al.Activated human T cells accomplish MHC class Ⅱ expression through T cell-specific occupation of class Ⅱ transactivator promoter Ⅲ[J].J Immunol,2002,168(2):763-770.
  • 9Waldburger JM,Suter T,Fontana A,et al.Selective abrogation of major histocompatibility complex class Ⅱ expression on extrahematopoietic cells in mice lacking promoter IV of the class Ⅱ transactivator gene[J].J Exp Med,2001,194(4):393-406.
  • 10Bontron S,Ucla C,Mach B,et al.Efficient repression of endogenous major histocompatibility complex class Ⅱ expression through dominant negative CⅡTA mutants isolated by a functional selection strategy[J].Mol Cell Biol,1997,17(8):4249-4258.

引证文献1

上海免疫学杂志
2002年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部