睡眠呼吸暂停综合征与Binswanger病的关系

Association between Sleep Apnea Syndrome and Binswanger's Disease

目的 研究睡眠呼吸暂停综合征在Binswanger病 (BD)中的作用。方法 84例BD患者 ,按 1∶1配对进行病例对照研究 ,分析两组患者的年龄及是否有睡眠呼吸暂停综合征、高血压、糖尿病、既往中风病史、高胆固醇血症、吸烟史等血管病危险因素。结果 在单因素Logistic回归分析中 ,睡眠呼吸暂停综合征、高血压、糖尿病及既往中风病史均为BD的影响因素 ;在多因素条件Logistic回归分析中 ,睡眠呼吸暂停综合征仍独立于其它因素而与BD相关联 (OR =2 .411,95 %CI值 1.0 6 6 - 5 .45 3 ;P =0 .0 34)。

Objective To investigate whether sleep apnea syndrome (SAS) is an risk factor for Binswanger's disease (BD). Methods 84 patients with or without BD were investigated. We analysed the clinical features such as the age, histories of SAS, hypertention, previous stroke, diabetes mellitus, hypercholesterolemia and smoking. Results In the univariate analysis, SAS, hypertention, previous stroke, diabetes mellitus are statistically significant risk factors for BD. Multiple conditional logistic regression analysis revealed that SAS is a significant risk factor when hypertention, previous stroke, diabetes mellitus as covariates in a logistic model (OR=2.411, 95% CI 1.066-5.453; P =0.034). Conclusion SAS is an risk factor for BD.