生物分子化学修饰用聚乙二醇衍生物的合成及应用

Synthesis and Application of Polyethylene Glycol Derivatives for the Chemical Modification of Biornacromolecules

聚乙二醇衍生物由于具有良好的生物相容性和免疫原性而被广泛应用于生物分子的化学修饰。本文就聚乙二醇衍生物的合成以及在生物医学和生物技术领域中的应用进行综述 ,主要包括聚乙二醇衍生物的分类 ,常用的聚乙二醇衍生物的合成方法及其性能 ,以及聚乙二醇衍生物的应用等。

Polyethylene glycol(PEG) and its derivatives,due to their good biocompatibility and low immunogenicity,have been widely used in the chemical modification of biomacromolecules.In this paper,the synthesis of polyethylene glycol derivatives and their utilization in biomedical and biochemical fields are briefly discussed,mainly centering on the classification,the synthesis methods,the performance evaluation,the application of polyethylene glycol derivatives.