摘要
Objective To establish an experimental model of symptomatic cerebral vasospasm(CVS) after subarachnoid hemorrhage(SAH)in rabbits. Method 2 weeks after the ligation of bilateral common carotid arteries, We induced CVS by injecting arterial blood twice via a cranial hole 2 mm×2 mm and then neurological symptoms ,cerebral blood flow(rCBF) and food intake were evaluated. Results Food intake and rCBF decreased and neurological disorders were observed. Conclusion An experimental rabbit model of symptomatic CVS can be established by injecting blood via a cranial hole after bilateral common carotid arteries ligation.
Objective To establish an experimental model of symptomatic cerebral vasospasm(CVS) after subarachnoid hemorrhage(SAH)in rabbits. Method 2 weeks after the ligation of bilateral common carotid arteries, We induced CVS by injecting arterial blood twice via a cranial hole 2 mm×2 mm and then neurological symptoms ,cerebral blood flow(rCBF) and food intake were evaluated. Results Food intake and rCBF decreased and neurological disorders were observed. Conclusion An experimental rabbit model of symptomatic CVS can be established by injecting blood via a cranial hole after bilateral common carotid arteries ligation.
出处
《中国临床康复》
CSCD
2002年第1期134-135,共2页
Chinese Journal of Clinical Rehabilitation
关键词
蛛网膜下腔出血
脑血管痉挛
神经功能失调
动物实验
subarachnoid hemorrhage
cerebral vasospasm
cerebral blood flow
neurological disorders
animal modelsCLC number:R743 Document code:A Article ID:1671-5926(2002)01-00134-02
