重复经颅磁刺激治疗轻型颅脑外伤后抑郁

The clinical research on the treatment of depression in patients with mild traumatic brain injury with repetitive transcranial magnetic stimulation

目的探讨重复经颅磁刺激(rTMS)对轻型颅脑外伤后抑郁(MTBID)患者的治疗效果。方法对16例MTBID患者予rTMS治疗,并观察其治疗前后汉密尔顿抑郁量表(HAMD)评分,事件相关电位(P300)及脑单光子发射计算机断层扫描(SPECT)显像变化。结果rTMS治疗的总有效率为87.5%,治疗后HAMD评分降低(P<0.05),P300潜伏期缩短(P<0.05)及脑血流灌注不足明显改善。结论rTMS对MTBID患者有治疗作用。

Objective To observe the effects of repetitive transcranial magnetic stimulation(rTMS) in the depressed patients with mild traumatic brain injury(MTBI).Method P300 and HAMD were measured in 16 depressed patients with MTBI, SPECT was performed on 6 depressed patients with MTBI, before and after rTMS.Result The total efficiency were 87.5%. At the end of trial, the latency of P300, regional cerebral blood flow(rCBF) of left frontal had significantly improved than those of before the treatment.Also, the scoring value of HAMD were markedly improved.Conclusion rTMS is effective and safe in treating depressed patients with MTBI.