流动注射在线过滤稀释原子吸收法测定药物制剂中卡托普利

Determination of Captopril by Flow Injection On-line Filtration-Dilution Atomic Absorption Spectrometry

提出了卡托普利的ＦＩ－ＡＡＳ分析新方法。它是基于在适当酸度条件下卡托普利将Ｃｕ^（２＋）还原为 Ｃｕ~＋．新生的Ｃｕ~＋与ＳＣＮ~－生成白色沉淀，经流动注射在线过滤稀释，以ＡＡＳ法测定反应剩余Ｃｕ^（２＋）的量来间接测定卡托普利的量。在２－１００ ｍｇ／Ｌ范围内呈良好的线性关系，回收率为９７．１％～９９．５％，采样频率为１００ｈ^（－１）。方法简单、快速、选择性好，节省试剂，用于卡托普利的测定．获得满意结果。

A simple, rapid and high selective method for the assay of captopril has been developed. It is based on the reaction of captopril with Cu2+ and SCN- to form precipitate quantitatively in aqueous solution. The amount of residual Cu2+ can be determined by flow injection on-line filtration-dilution-atomic absorption spectrometry, then the content of captopril can be determined indirectly. The linear range is 2similar to100 mg/L, the recovery is 97.1%similar to99.5%, the sampling frequency is 100/h. The method has been applied to determine captopril with satisfactory result.