盐酸氨溴索在碳糊电极上阳极伏安法的研究

Anodic Voltammetric Behavior of Ambroxol at the Carbon Paste Electrode

在０．５ ｍｏｌ／Ｌ Ｈ２ＳＯ４底液中，用碳糊电极阳极伏安法测定盐酸氨溴索，被测的阳极峰电位为１．１０Ｖ（ｖｓ．ＳＣＥ），另外，在０．４６Ｖ处还产生一对可逆的氧化还原峰。１．１０ Ｖ处的峰电流与盐酸氨溴索的浓度在３．９８×１０^（－７）～６．３４ × １０^（－５）ｍｏｌ／Ｌ范围内呈良好的线性关系，该方法的检出下限为３．０ × １０^（－８）ｍｏｌ／Ｌ。用标准加入法测得回收率范围为９２．８％～１０２％，ＲＳＤ为２．９％（ｎ＝１０）。对电极响应机理进行了初步探讨，氨溴索在１．１０ Ｖ处的氧化为不可逆过程，其氧化产物在０．４６０Ｖ处产生一对２电子２质子受扩散控制的可逆波，用该波也可进行定量测定并且干扰较少，但灵敏度略低。

The ambroxol hydrochloride was determined with a carbon paste electrode by the anodic voltammetry at 1.10 V (vs. SCE) in 0.5 mol/L H2SO4. Another redox couple of ambroxol appeared at 0.46 V. The peak currents at 1.10 V are proportional to ambroxol concentration in the range of 3.98 x 10(-7) similar to 6.34 x 10(-5) mol/L with the detection limit of 3.0 x 10(-8) mol/L. The range of recovery is 92.8% similar to 102% by the standard addition, and RSD is 2.9% (n = 10). The response mechanism of the electrode was discussed. The anodic oxide of amboroxol at 1.10 V is irreversible. The oxidic product of amboroxol has a redox couple waves at 0.46 V which is characteristic of two electrons and two protons process and reversible diffusion-controlled process. These couple waves can also be employed for quantitative determination of ambroxol with fewer interference but lower sensitivity.