市售西咪替丁和双嘧达莫抗森林脑炎病毒作用的研究

Study on effect of cimetidine and dipyridamole in the anti-tick-borne encephalitis viruses

目的 探讨西咪替丁与双嘧达莫对感染森林脑炎病毒的小鼠的死亡保护作用。方法 将不同浓度的西咪替丁和双嘧达莫经腹腔注射给已感染森林脑炎病毒的小鼠 ,同时设立对照组。结果 西咪替丁与双嘧达莫均可延长感染病毒鼠的平均存活天数 (P均小于 0 .0 5) ,西咪替丁还可降低小鼠的死亡率 (P <0 .0 5) ,但未观察到随西咪替丁浓度的增加有降低死亡率的特点。

Objective To study the anti tick borne encephalitis virus effect of cimetidine and dipyridamole.Methods Cimetidine and dipyridamole were injected to the mice affected tick borne encephalitis virus in the different doses twice daily for 15 days.Results Cimetidine and dipyridamole could both elongate the average life time of the mice affected tick borne encephalitis virus( P <0.05).Cimetidine could decease the death rate of the mice affected tick borne encephalitis virus( P < 0.05 ).Conclusion Cimetidine and dipyridamole have anti tick borne encephalitis effect.