阿莫西林-克拉维酸序贯治疗急性细菌性感染在急诊科的应用

Amoxicillin/clavulanic acid in sequential treatment of acute bacterial infection in emergency department

目的 :评价阿莫西林 克拉维酸治疗急性细菌性感染的有效性和安全性。方法 :用阿莫西林 克拉维酸治疗呼吸道感染 6 6例 ,泌尿系感染 31例和消化道感染 16例共 113例 (男性 6 1例 ,女性 5 2例 ,年龄 39a±s 16a)。静脉注射 1.2 g ,每日 2～ 3次 ,5d± 3d后改为 0 .375～ 0 .75 g口服 ,每日 3次 ,总疗程 7～ 14d。结果 :阿莫西林 克拉维酸治疗各类感染总有效率分别为 94 % (6 2 / 6 6 ) ,91% (2 8/ 31)和 94 % (15 / 16 )。 113例中分离出 73株致病菌 ,对阿莫西林 克拉维酸敏感率 82 % ,细菌清除率 86 %。不良反应为食欲减退和一过性肝功能异常 ,占 5 %。结论 :阿莫西林 克拉维酸对急性细菌性感染疗效好 ,不良反应轻微 。

AIM: To evaluate the efficacy and safety of amoxicillin/clavulanic acid in sequestial treatment of acute bacterial infection. METHODS: A total 113 patients (M 61, F 52; age 39 a± s 16 a) consisted of respiratory tract (66 patients), urinary tract (31 patients) and gastrointestinal tract (16 patients) infection were treated with amoxicillin/clavulanic acid injection 1.2 g, iv, bid or tid for 5 d±3 d, then amoxicillin/clavulanic acid tablet 375 750 mg, po , tid for 7-14 d. RESULTS: The total effective rate of amoxicillin/clavulanic acid was 94%(62/66), 91%(28/31),94%(15/16)respectively. Sensitivity of bacteria was 82%, the becteria logical clearance rate was 86%, the adverse reaction rate was 5%. CONCLUSION: Amoxicillin/clavulanic acid has excellent clinical efficacy in the treatment of acute bacterial infection, little and mild adverse reaction. Amoxicillin/clavulanic acid can be the first line antibiotiics in emergency department.