奥曲肽对脑出血并发上消化道出血的疗效

Effect of octreotide in treatment of upper alimentary tract hemorrhage followed cerebral hemorrhage

目的 :观察奥曲肽对脑出血并发上消化道出血的疗效。方法 :78例脑出血病人随机分为第 1组 2 7例 ,第 2组 2 5例 ,第 3组 2 6例。全部病人按常规方案治疗脑出血。第 1组加用奥曲肽 (首剂0 .1mg ,iv ,继后 0 .3mg ,ivgtt ,qd) ,疗程 3d。第 2组加用法莫替丁 (40mg ,ivgtt ,qd) ,疗程 7d。第 3组不用奥曲肽或法莫替丁。观察上消化道出血和死亡的发生例数。结果 :第 1组的上消化道出血及死亡发生率显著低于第 3组 (7%和 7%vs 38%和31% ) ,P <0 .0 1。第 2组与第 3组的上消化道出血发生率 (12 %vs 38% ) ,P <0 .0 5。第 1组与第 2组出血率和死亡率 (7% ,7%vs 12 % ,8% ) ,P >0 .0 5。结论

AIM: To observe the effect of octreotide in treating upper alimentary tract hemorrhage followed cerebral hemorrhage. METHODS: Seventy eight patients with cerebral hemorrhage were randomly divided into three groups. Besides conventional therapy, the first group of 27 patients (M 20, F 7; age 59 a± s 15 a) was treated with octreotide (first dose 0.1 mg, iv, then 0.3 mg, iv drip, qd× 3 d ). The second group of 25 pationts (M 19, F 6; age 59 a±14 a) was treated with famotidine (40 mg, iv drip, qd×7 d). The third group of 26 patients (M 20, F 6; age 60 a±16 a) was treated without octreotide or famotidine. Patients of upper alimentary tract hemorrhage and death were recorded during hospitalization. All of the results among groups would be disposed by χ 2 test. RESULTS: The rate of upper alimentary tract hemorrhage and death of the first group was very signification lower than the third group 7%, 7% vs 38%, 31% ( P <0.01). The rate of hemorrhage of the second group significant lower than the third group 12% vs 38% ( P < 0.05 ). There was no significant difference of the rate of hemorrhage and death between the first group and the second group, 7%, 7% vs 12%, 8%( P > 0.05). CONCLUSION: Octreotide is good for treatment of upper alimentary tract hemorrhage followed cerebral hemorrhage.