糖尿病患者唾液GSH-Px活性研究

A study on the activity of GSH-Px in saliva of the patients with diabetes

目的 探讨唾液谷胱甘肽过氧化物酶 (GSH Px)与糖尿病的关系。方法 选择 5 6例糖尿病 (3 6例患牙周炎 ,2 0例无牙周炎 )及 3 3例正常对照者 ,采用DTNB显色法 ,测定唾液GSH Px含量。结果 糖尿病组GSH Px含量明显低于正常对照组 (P <0 .0 5 ) ,糖尿病伴牙周炎组GSH Px含量与正常对照组有显著性差异 (P <0 .0 5 ) ,而糖尿病无牙周炎组GSH Px含量与正常对照组无显著性差异 (P >0 .0 5 )。结论 糖尿病影响牙周炎的发生、发展 ,牙周炎与GSH Px关系密切 ,而糖尿病可间接导致GSH Px含量降低。

Objective To investigate the relationship of GSH Px in saliva with diabetes. Methods The auther used DTNB to measure GSH Px in saliva from 56 cases of diabetes, and 33 normal controls. Results The levels of GSH Px were lower than that of normal controls( P < 0.05 ). The difference between diabetes (with periodontitis) group and normal controls were significant ( P < 0.05 ). The difference between diabetes (without periodontitis) group and normal controls were not significant ( P > 0.05 ). Conclusion The diabetes could affect periodontitis. Reduction of GSH Px may be caused by increased consumption of GSH Px for more free radicals produced. So we infered diabetes can affect the levels of GSH Px.