新疆部分维族、汉族口腔黏膜癌前病变及口腔鳞状细胞癌P_(16)蛋白表达的研究

Study on the expression of P_(16) protein in oral precancerous lesions and oral squamous Cell Carcinoma in Uygur and Hans patients in xinjiang

目的 探讨新疆维吾尔族、汉族口腔黏膜癌前病变及口腔鳞状上皮细胞癌的发生与发展过程中P16蛋白表达的意义。方法 采用免疫组化LSAB法对 40例口腔扁平苔藓 (维吾尔族 2 0例 ,汉族 2 0例 ) ,43例口腔白斑 (维吾尔族 2 3例 ,汉族 2 0例 )和 65例口腔鳞状上皮细胞癌 (维吾尔族 2 4例 ,汉族 41例 )分别进行检测。结果口腔鳞状上皮细胞癌组织中P16蛋白阳性率为 3 2 .3 % ,明显低于口腔白斑 (5 5 .8% )和口腔扁平苔藓 (72 .5 % ) ,P <0 .0 0 5 ,维族与汉族之间的差异均无统计学意义 (P >0 .0 5 )。结论 P16蛋白表达缺失在口腔鳞状上皮细胞癌的发生与发展过程中起重要作用 ;据本研究资料 。

Objective To explore the expression of P 16 protein and its significance during the development and progression of oral precancerous lesions and oral squamous cell carcinoma(OSCC) in Uygur and Hans patients in Xinjiang. Methods Expression of P 16 protein was detected in 40 cases of oral lichen planus(OLP), 43 cases of oral leukoplakia(OLK) and 65 cases of OSCC in Uygur and Hans patients by immunohistochemical techniques. Results The positive rates of P 16 pretein was lower in OSCC ( 32.3 %) than in OL( 55.8 %) and OLP( 72.5 %,( P < 0.005 );no significant difference between Uygur and Hans patients was found ( P > 0.05 ). Conclusions The low expression of P 16 protein may play important roles in oscc development and progression. So far there is no significant difference in expression of P 16 protein between Uygur and Hans.