中国重庆地区汉族群体白介素-1受体拮抗剂基因多态性分布的初步观察

Polymorphisms of IL-1Ra gene in Han population in Chongqing

目的 从基因水平上了解中国重庆地区汉族人群白细胞介素 1受体拮抗剂 (IL 1Ra)基因多态性分布。方法 采用PCR方法对 112例重庆地区汉族健康人IL 1Ra基因VNTR多态性进行了观察 ,并结合文献进行了不同种族间的分析比较。结果 中国重庆地区正常人群以IL 1RaA1等位基因频率最高 ,IL 1RaA2等位基因次之 ,与德、美等西欧国家及非洲白人相比 ,重庆地区汉族人IL 1RaA1等位基因的频率明显要高 ,IL 1RaA2等位基因频率明显低 ,而与非洲黑人相近。重庆地区汉族人IL 1RaA1 A1、A1 A2、A2 A2基因型分别为 0 .83、0 .17、0。结论 IL 1Ra基因VNTR基因多态性在不同种族间的分布存在着明显的差异 ,为进一步研究IL

Objective To study genotype and allele distributions of IL 1Ra VNTR in Han population in Chongqing and make comparason with different races. Methods The VNTR polymorphism of IL 1Ra were examined in 112 controls with polymerase chain reaction methods. Results The A1/A1 genotype was the most frequent one and the A1/A2 the second. Compared with Germany,American and white South African populations, the frequency of IL 1A1 allele in Han population in Chongqing was higher, While IL A2 allele lower, which was similar with the black South African. In Han population in Chongqing, the frequency of IL 1RaA1/A1?A1/A2?A2/A2 genotype were 0.83?0.17?0,respectively. Conclusions VNTR polymorphism of IL 1Ra gene are different in different ethnic populations, which may be of significance in the studies on relationship between genetics and disease association.